BAY 73-1449
CAS No. : 693790-96-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $400 | In-stock |
| 25mg | $690 | In-stock |
| 50mg | $985 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-118941 |
| M.Wt: | 425.48 |
| Formula: | C26H23N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1].
IC50 & Target: prostacyclin receptor[1]
In Vivo: BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats[1].
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats[1].
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats[1].
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