Buprofezin
CAS No. : 69327-76-0
| Size | Price | Stock |
|---|---|---|
| 50mg | $32 | In-stock |
| 100mg | $60 | In-stock |
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| Cat. No. : | HY-B0831 |
| M.Wt: | 305.44 |
| Formula: | C16H23N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].
In Vitro: Buprofezin (100, 300, 1000 µM) significantly reduces viability of HepG2 cells[1].
Buprofezin (3, 10, 30 µM; 24 h) promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis in HepG2 cells[1].
Buprofezin (3, 10, 30 µM; 24 h) inhibits the activity of Complex IV in HepG2 cells[1].
In Vivo: Buprofezin (46.3, 139, 417 mg/kg; p.o.; single) accumulates in the liver (35.84%), brain (23.58%), stomach (21.94%) and kidney (18.64%)[1].
Buprofezin (46.3, 139, 417 mg/kg; p.o.; single) elevates the MDA level in all organs (especially in the liver and brain) in mice[1].
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