trans-Vaccenic acid

trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity^[1][2][3]. In Vitro:trans-Vaccenic acid is reduced in the rumen to form stearic acid or is desaturated by Δ9-desaturase in the mammary tissue to produce cis-9, trans-11 C18:2, which is an abundant conjugated Linoleic acid isomer in meat and milk^[1].
trans-Vaccenic acid (0-200 μM; 24 h) inhibits NPC cell viability in a dose-dependent manner^[2].
trans-Vaccenic acid (25-100 μM; 24 h) induces apoptosis in NPC cells in a dose-dependent manner. trans-Vaccenic acid significantly increases the levels of cleaved PARP and cleaved caspase-3 in a time-dependent manner^[2].
trans-Vaccenic acid (25-100 μM; 24 h) induces apoptosis in NPC cells through Akt and bad inactivation^[2].
In Vivo:trans-Vaccenic acid (1% w/w; diet; for 8 weeks) alleviates features of metabolic syndrome (MetS) potentially by remodeling adipose tissue and attenuating ectopic lipid accumulation in a rat model of obesity and MetS^[3].