Pinoresinol 4-O-β-D-glucopyranoside
CAS No. : 69251-96-3
(Synonyms: (+)-Pinoresinol 4-O-β-D-glucopyranoside)
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| 10mg | $200 | In-stock |
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| Cat. No. : | HY-N2168 |
| M.Wt: | 520.53 |
| Formula: | C26H32O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects[1][2][3][4][5][6][7][8].
In Vitro:Pinoresinol 4-O-β-D-glucopyranoside (0.1 μM-0.1 mM; 24 h) activates estrogen receptor (ER)-dependent transcription of both transfected and endogenous target genes in Hela cells and MCF-7 cells, and induces pS2 mRNA expression in MCF-7 cells in a dose-dependent manner[1].
Pinoresinol 4-O-β-D-glucopyranoside shows no inhibitory activity against A/PR/8/34 (H1N1) virus in MDCK cells[2].
Pinoresinol 4-O-β-D-glucopyranoside shows promising antioxidant activity with an IC50 of 34.5 μg/mL in the ABTS assay[4].
Pinoresinol 4-O-β-D-glucopyranoside exhibits a potent α-glucosidase inhibition, with an IC50 of 48.13 μg/mL[4].
Pinoresinol 4-O-β-D-glucopyranoside (2.5-150 μg/mL) displays a substantial antioxidant activity in the DPPH scavenging capacity assay, with an IC50 of 44.2 μg/mL and a TAC of 737.7 μmol/g[7].
In Vivo:Pinoresinol 4-O-β-D-glucopyranoside (50 mg/kg; p.o.; 20 days for hepatoprotective activity test, 10 days for antihyperglycaemic activity test) exhibits hepatoprotective activity by lowering AST and ALT levels in CCl4 (HY-Y0298)-induced hepatotoxicity mice, and shows antihyperglycaemic activity by causing a prominent decline in serum glucose level and a promising elevation in insulin level in Streptozotocin (HY-13753)-treated mice[4].
Pinoresinol 4-O-β-D-glucopyranoside (25-50 mg/kg; p.o.; twice with the second dose 1 h before pilocarpine injection) ameliorates the seizures in a dose-dependent manner in lithium/Pilocarpine (HY-B0726A)-induced epileptic seizures rats, manifested by retarding seizure onset, reducing the number of rats developing seizures, and enhancing the survival of animals after seizure exposure[7].
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