AZD0424
CAS No. : 692054-06-1
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| Cat. No. : | HY-112314 |
| M.Wt: | 528.99 |
| Formula: | C25H29ClN6O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2]. IC50 & Target: Src/Abl kinase inhibitor (SrcK-I), apoptosis[1] In Vitro: AZD0424 (1-5 μM; 24-48 hours) is emerged to be the more effective of the three tested inhibitors (AZM559756, AZD0530 and AZD0424), inducing the highest levels of apoptosis with the lowest concentrations in lymphoma cells[2]. AZD0424 (5 μM; 48 hours) leads to increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells, whereas the cell cycle progression of the nonsensitive cell lines Raji and Jurkat remains unaffected[2].
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