1,2-Hexanediol

1,2-Hexanediol (Hexane-1,2-diol) is a broad-spectrum antibacterial agent. 1,2-Hexanediol exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as antifungal activity against fungal organisms. 1,2-Hexanediol disrupts the cytoplasmic membrane potential of bacteria. 1,2-Hexanediol can be used in research on bacterial and fungal infections, as well as cosmetic preservation^[1][2]. In Vitro:1,2-hexanediol (195-100000 ppm; 24-72 h) inhibits the growth of Escherichia coli NCTC 12923, Staphylococcus aureus NCTC 10788, Candida albicans NCPF 3179, and Aspergillus brasiliensis NCPF 2275, with MIC values of 12500, 25000, 12500, and 6250 ppm, respectively^[1].
1,2-hexanediol (0-25000 ppm; 24-48 h) exerts synergistic inhibitory effects with Nicotinamide (HY-B0150) against Candida albicans NCPF 3179 and Aspergillus brasiliensis NCPF 2275, with FICI values of 0.375 and 0.3125, respectively; it exerts synergistic inhibitory effects with sodium cocoyl methyl taurate and sodium cocoyl alaninate against Escherichia coli NCTC 12923, with an FICI value of 0.375 for each combination; it also exerts a synergistic inhibitory effect with sodium C14-16 olefin sulfonate against Aspergillus brasiliensis NCPF 2275, with an FICI value of 0.375^[1].
1,2-Hexanediol disrupts the cytoplasmic membrane potential of B. cereus ATCC 21772^[2].