PIK-C98
CAS No. : 691388-62-2
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| Cat. No. : | HY-12491 |
| M.Wt: | 349.23 |
| Formula: | C16H10Cl2N2OS |
| Purity: | >98 % |
| Solubility: |
PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].
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