Sapropterin (dihydrochloride)
CAS No. : 69056-38-8
(Synonyms: (6R)-BH4 (dihydrochloride); (6R)-Tetrahydro-L-biopterin (dihydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $80 | In-stock |
| 50mg | $96 | In-stock |
| 100mg | $168 | In-stock |
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| Cat. No. : | HY-A0124A |
| M.Wt: | 314.17 |
| Formula: | C9H17Cl2N5O3 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE)[1][2]. In Vitro:Sapropterin dihydrochloride enhances residual phenylalanine hydroxylase activity to increase phenylalanine oxidation[1]. In Vivo:Sapropterin (100 mg/kg/day; oral; daily; 22 days) dihydrochloride treatment aggravates primary progressive and relapsing-remitting EAE in SJL/J mice, as evidenced by increased clinical EAE scores, elevated plasma long-chain ceramide levels, reduced linolenic acid levels, and increased spinal cord T-cell infiltration[2].
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