Nedocromil sodium
CAS No. : 69049-74-7
(Synonyms: FPL 59002KP; Nedocromil disodium salt)
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| Cat. No. : | HY-16344 |
| M.Wt: | 415.30 |
| Formula: | C19H15NNa2O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.2 mg/mL (ultrasonic) |
Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). IC50 & Target: Histamine, LTC4, PGD2[1] In Vitro: Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1]. In Vivo: Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function[2].
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