Tiotidine
CAS No. : 69014-14-8
(Synonyms: ICI 125211)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $870 | In-stock |
| 250mg | $1480 | In-stock |
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| Cat. No. : | HY-101232 |
| M.Wt: | 312.42 |
| Formula: | C10H16N8S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors[1][2].
In Vitro: Tiotidine competitively antagonizes the positive chronotropic action of histamine with an apparent dissociation constant of 30 μM (23-38 μM). Tiotidine abolishes H2-mediated increases in contractile force leaving H2-mediated negative inotropic responses unopposed. The actions of histamine at the A-V node, manifested by lengthening of the P-R interval and A-V block, are attenuated by 2.5 x 10(-7) M Tiotidine[2].
Tiotidine actually behaves as an inverse agonist in U-937 cells, diminishing basal cAMP levels[3].
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