Toltrazuril (sulfone)
CAS No. : 69004-04-2
(Synonyms: Ponazuril)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $93 | In-stock |
| 50mg | $125 | In-stock |
| 100mg | $145 | In-stock |
| 500mg | $260 | In-stock |
| 1g | $365 | In-stock |
| 5g | $657 | In-stock |
| 10g | $855 | In-stock |
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| Cat. No. : | HY-17008 |
| M.Wt: | 457.38 |
| Formula: | C18H14F3N3O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry[1][2].
IC50 & Target:Anticoccidial[1]
In Vitro: Toltrazuril sulfone inhibits the development of merozoites of S. neurona[1].
Toltrazuril sulfone inhibits the development of N. caninum after approximately 48 h post-exposure[1].
Toltrazuril sulfone exhibits inhibitory possibly by targeting different enzyme/enzyme systems in different apicomplexans[1].
Toltrazuril sulfone (5 mg/ml; 20 hours) inhibits T. gondii replication after the second division by endodyogeny[2].
In Vivo: Toltrazuril sulfone (10-20 mg/kg; p.o.; daily; for 10 days) is effective in preventing and treating toxoplasmosis in mice[2].
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