Eledoisin
CAS No. : 69-25-0
(Synonyms: Eledone peptide)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $144 | In-stock |
| 25mg | $288 | In-stock |
| 50mg | $450 | In-stock |
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| Cat. No. : | HY-P0006 |
| M.Wt: | 1188.40 |
| Formula: | C54H85N13O15S |
| Purity: | >98 % |
| Solubility: | H2O : 18.15 mg/mL (ultrasonic;warming) |
Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors. IC50 & Target:NK2 and NK3 receptors[1]. In Vitro: Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1]. In Vivo: Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2].
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