Fluphenazine
CAS No. : 69-23-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $270 | In-stock |
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| Cat. No. : | HY-119980 |
| M.Wt: | 437.52 |
| Formula: | C22H26F3N3OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].
IC50 & Target:Dopamine receptor, Sodium channels, SARS-CoV-2[1][2]
In Vivo:Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].
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