Kahweol
CAS No. : 6894-43-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $247 | In-stock |
| 10mg | $396 | In-stock |
| 20mg | $635 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N6258 |
| M.Wt: | 314.42 |
| Formula: | C20H26O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33.33 mg/mL |
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. IC50 & Target:AMPK; adipogenesis; apoptosis[1] In Vitro: Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells[1]. Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells[1]. Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only[1]. kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells[2]. kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism[2].
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