DTE
CAS No. : 6892-68-8
(Synonyms: Dithioerythritol; Cleland’s reagent)
| Size | Price | Stock |
|---|---|---|
| 1g | $16 | In-stock |
| 10g | $65 | In-stock |
| 25g | $130 | In-stock |
| 100g | $386 | In-stock |
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| Cat. No. : | HY-15916 |
| M.Wt: | 154.25 |
| Formula: | C4H10O2S2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
DTE (Dithioerythritol) is a sulfur-containing sugar derived from the corresponding 4-carbon monosaccharide erythrose. DTE is an epimer of Dithiothreitol (DTT) (HY-15917). DTE is a thiol reducing agent[1].
In Vitro:DTE (0-10 mM, 30 min) compensates for the inhibitory effect of TPT on human sex steroid hormone metabolism related enzymes by protecting the cysteine through reduction, EC50s for 17β-HSD 1, P450arom, 3α-HSD 2 and 17β-HSD 3 are 0.21, 0.91, 0.9 and 12.9 mM, respectively[1].
DTE (0-2 mM, 24 h) improves sperm quality after freezing-thawing by inhibiting the oxidative stress and protecting sperm membrane integrity[2].
In Vivo:DTE (0.25%-1% v:v in drinking water) exhibits antioxidant activity, and alleviates liver and kidney injury in mouse bile duct ligation (BDL) models[2].
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