Metioprim
CAS No. : 68902-57-8
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| Cat. No. : | HY-122289 |
| M.Wt: | 306.38 |
| Formula: | C14H18N4O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria[1][2].
In Vitro:Metioprim inhibits some anaerobic bacteria species with an average MIC value of 3.2 μg/mL[1].
Metioprim (0-1.0 μM; 0-8 h) suppresses bacterial growth kinetics, and inhibits E. coli with an MIC value of 0.7 μg/mL[2].
In Vivo:Metioprim (5 mg/kg or 10 mg/kg; i.v.; single dose) has a shorter elimination half-life in goat than in pig (23 min vs 169 min), and its main metabolites are methionine sulfoxide and methoxysulfonic acid[3].
Pharmacokinetic Analysis[1]
| Animal | Route | Dose (mg/kg) | C0 (μg/mL) | A (μg/mL) | α (1/min) | t1/2α (min) | B (μg/mL) | β (1/min) | t1/2β (min) | VC (1/kg) | Vp (1/kg) | Vd,ss (1/kg) | Clβ (mL/min/kg) |
| Pigs | i.v. | 5 | 3.6 | 2.1 | 0.032 | 25 | 1.5 | 0.00415 | 169 | 1.45 | 0.74 | 2.19 | 10.0 |
| Goats | i.v. | 10 | 12.2 | 6.4 | 0.220 | 4 | 5.6 | 0.03138 | 23 | 0.85 | 0.44 | 1.28 | 49 |
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