SPL-334
CAS No. : 688347-51-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $252 | In-stock |
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| Cat. No. : | HY-110295 |
| M.Wt: | 433.50 |
| Formula: | C22H15N3O3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1]. In Vivo:SPL-334 (0.1-1 mg/kg; Intranasal administration; daily, for 7 d; BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft) causes a reduction in allergic airway inflammation[1].
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