Dipotassium glycyrrhizinate
CAS No. : 68797-35-3
(Synonyms: Glycyrrhizic acid (dipotassium); Dipotassium glycyrrhizate)
| Size | Price | Stock |
|---|---|---|
| 50mg | $50 | In-stock |
| 100mg | $80 | In-stock |
| 500mg | $240 | In-stock |
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| Cat. No. : | HY-N0184A |
| M.Wt: | 899.11 |
| Formula: | C42H60K2O16 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C) |
Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity[1][2][3].
In Vitro:Dipotassium glycyrrhizinate (0-400 μM, 4 days) inhibits mRNA level of atopic dermatitis related genes (NELL2, CA2, AQP3, and HAS3 gene level) in IL‑4‑ and IL‑13‑induced keratinocytes[1].
Dipotassium glycyrrhizinate (0-400 μM, 4 days) partially repaired the atopic dermatitis-like phenotype (the spongiosis like intercellular spaces) in the IL-4/IL-13-induced AD-like skin equivalent model[1].
Dipotassium glycyrrhizinate (0-100 μM, 24 h) inhibits Sunitinib-induced autophagy, cardiomyocyte death in CCC-HEH-2 cells[4].
In Vivo:Dipotassium glycyrrhizinate (150 mg/kg, i.p.) reduces plasma glucose and increases plasma GLP-1 in Streptozotocin (65 mg/kg, i.p.) induced type 1-like diabetic rats[2].
Dipotassium glycyrrhizinate (50 mg/kg, i.p., once daily for 4 weeks) inhibits thyroiditis in the Iodine-induced murine model of autoimmune thyroiditis[3].
Dipotassium glycyrrhizinate (50-200 mg/kg, i.p.,) inhibits Bleomycin (HY-108345)-induced pulmonary fibrosis IN rats[5].
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