Triclabendazole
CAS No. : 68786-66-3
(Synonyms: CGA89317)
| Size | Price | Stock |
|---|---|---|
| 25mg | $35 | In-stock |
| 50mg | $55 | In-stock |
| 100mg | $80 | In-stock |
| 200mg | $120 | In-stock |
| 500mg | $210 | In-stock |
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| Cat. No. : | HY-B0621 |
| M.Wt: | 359.66 |
| Formula: | C14H9Cl3N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica[1][2][3].
In Vitro:Triclabendazole (20-320 μM, 24-48 h) has cytotoxicity on MCF-7 and MDA-MB-231 cells[1].
Triclabendazole (40-160 μM, 24 h) induces apoptosis in MCF-7 and MDA-MB-231 cells[1].
Triclabendazole (0.97-500 μM, 48-72 h) have low cytotoxicity in Macrophages[3].
Triclabendazole (45.67 μM, 72 h) shows significant alterations in cell cycle with a decrease in G1 from 74.6% to 54.3% and an increase in S and G2 from 9.7% to 16.6% and 11.9% to 25.4%, respectively phases in promastigotes[3].
In Vivo:Triclabendazole (20-100 mg/kg, Intraperitoneal injection, twice a week for 2 weeks) has anti-tumor effect in the xenograft MDA-MB-231 cells model nude mice[1].
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