Corynoxine
CAS No. : 6877-32-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $82 | In-stock |
| 5mg | $174 | In-stock |
| 10mg | $306 | In-stock |
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| Cat. No. : | HY-N0901 |
| M.Wt: | 384.47 |
| Formula: | C22H28N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway[1].
In Vitro: Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner[1].
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction[1].
In Vivo: Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice[2].
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila[1].
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