IWP-4 (GMP)
CAS No. : 686772-17-8
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| Cat. No. : | HY-12879G |
| M.Wt: | 496.62 |
| Formula: | C23H20N4O3S3 |
| Purity: | >98 % |
| Solubility: |
IWP-4 (GMP) is the GMP-grade form of IWP-4 (HY-12879). IWP-4 is a Wnt inhibitor with an IC50 of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC50 of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC50 = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure[1][2][3].
In Vitro:IWP-4 (GMP) (48 h) inhibits the proliferation of all tested cancer cell lines, with submicromolar EC50 values ranging from 0.23 μM to 0.93 μM[1].
IWP-4 (GMP) (1 μM; 24 h) antagonizes the protective effect of ginkgolide B on primary rat cortical astrocytes against glutamate-induced injury by reversing ginkgolide B-mediated regulation of apoptosis-related genes and proteins, as well as glutamate transporter genes and proteins[2].
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