Kojic amine

Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [³H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia^{[1][2]In Vitro:Kojic amine (Compound 3) potently and specifically inhibits the Na+-independent binding of [3H]GABA to rat brain cell membranes[1]. In Vivo:kojic amine i.v.(i.v.) reduces flexor reflex spasm in rats with chronic spinal cord injury by 70%, with an ED₇₀ of 8 mg/kg for intravenous delivery[1].
Kojic amine (i.v., oral administration; cumulative dosing) reduces flexor reflex spasm in chronic spinal cats by 70%, with an intravenous ED₇₀ of 2.2 mg/kg and an oral ED₇₀ of 4 mg/kg[1].
Kojic amine (15-128 mg/kg; i.g.; single dose) prevents 3-mercaptopropionic acid-induced tonic extensor convulsions in 50% of mice at an oral ED₅₀ of 15 mg/kg[1].
Kojic amine (8.2-15.7 mg/kg; i.p.; single administration) produces dose-dependent, short-acting analgesic effects in the mouse hot-plate test at 48°C and 55°C, with ED₅₀ values of 9.2 mg/kg and 13.8 mg/kg, respectively[2].}