PPARδ agonist 10
CAS No. : 685139-10-0
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| Cat. No. : | HY-121542 |
| M.Wt: | 568.71 |
| Formula: | C23H17Br2ClO3S |
| Purity: | >98 % |
| Solubility: | 10 mM in Ethanol |
PPARδ agonist 10 (compound 7) is an orally active, selective, and partial agonist of PPARδ, with EC50 values of 0.053 μM and 0.30 µM for hPPARδ(LBD)-GAL4 and mPPARδ, respectively. PPARδ agonist 10 is a partial PPARδ agonist in transactivation assay but a full agonist on free fatty acids (FFA) oxidation in muscle cells both in vitro and in vivo. PPARδ agonist 10 can be used for dyslipidemia research[1].
In Vitro:PPARδ agonist 10 (compound 7) increases fatty acid oxidation in rat L6 muscle cells, with EC50 of 30 nM[1].
In Vivo:PPARδ agonist 10 (compound 7) changes plasma lipid parameters in a dose-dependent manner to a less atherogenic profile[1].
PPARδ agonist 10 (5-20 mg/kg, PO, once daily) shows good oral pharmacokinetic properties in rat[1].
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