Acoltremon
CAS No. : 68489-09-8
(Synonyms: WS-12; AR-15512; AVX-012)
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
| 500mg | $1500 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-108449 |
| M.Wt: | 289.41 |
| Formula: | C18H27NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].
IC50 & Target:EC50: 39 nM (TRPM8)[1]
In Vitro:Acoltremon (10 μM) shows TRPM8 agonism in tests on heterologously expressed TRP ion channels[1].
Acoltremon (1 or 10 μM; 0-250 s) shows highly potent and specific TRPM8 channel agonist in DRG neurons[1].
In Vivo:Acoltremon (intraperitoneal injection; 10 mg/kg; once) shows analgesic effect by selective TRPM8 activation in mice[1].
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