Anagrelide
CAS No. : 68475-42-3
| Size | Price | Stock |
|---|---|---|
| 25mg | $147 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $330 | In-stock |
| 250mg | $660 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-B0523 |
| M.Wt: | 256.09 |
| Formula: | C10H7Cl2N3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
IC50 & Target:PDEIII[1]
In Vitro:Anagrelide potently inhibits the development of marrow megakaryocytes (IC50=26 nM)[1].
Anagrelide (0.05, 0.3, 1 µM; 12-day) inhibits only megakaryocytic cell growth not non-megakaryocytic cells[2].
Anagrelide (0.1-10000 nM) induces a cytotoxic effect in the GIST882 cell line[3].
In Vivo:Anagrelide (5 mg/kg/bid; for 10 days) inhibits or reduces tumor growth in GIST2B, GIST9, GIST882 model models[3].
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