BMS-986187
CAS No. : 684238-37-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $650 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120613 |
| M.Wt: | 470.60 |
| Formula: | C31H34O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB?of 6.02 (～1?μM). BMS-986187 has no observable PAM activity at the?μ-receptor (EC50=3 μM)[1].
In Vitro: BMS-986187?(1 nM-100 uM) produces little or no activity in agonist mode, but in PAM mode (in the presence of an EC20?of leu-enkephalin (in CHO-OPRD1 cells) or endomorphin 1 (in CHO-OPRM1 cells)) produces a response with an EC50?of 48 nM in CHO-OPRD1 cells and 2?μM in CHO-OPRM1 cells[1].
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