Orotic acid (zinc)
CAS No. : 68399-76-8
(Synonyms: 6-Carboxyuracil (zinc); Vitamin B13 (zinc))
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| 500mg | $119 | In-stock |
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| Cat. No. : | HY-N0157A |
| M.Wt: | 188.79 |
| Formula: | C5H4N2O4Zn0.5 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;adjust pH to 2 with 1 M HCL) |
Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].
In Vitro: Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].
In Vivo: Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].
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