NSC16168
CAS No. : 6837-93-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $170 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $486 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-100690 |
| M.Wt: | 473.50 |
| Formula: | C17H15NO9S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic) |
NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer[1].
IC50 & Target: IC50: 0.42 μM (ERCC1-XPF)[1].
In Vitro: NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells[1].
In Vivo: NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts[1].
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