Nonactin
CAS No. : 6833-84-7
(Synonyms: Ammonium ionophore I)
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|---|---|---|
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| 10mg | $290 | In-stock |
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| Cat. No. : | HY-N6790 |
| M.Wt: | 736.93 |
| Formula: | C40H64O12 |
| Purity: | >98 % |
| Solubility: | DMF : 50 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 6.67 mg/mL (ultrasonic) |
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity[1][2][3][4]. In Vitro:Nonactin (0.01-10 μM; 24 h) induces apoptosis in β-catenin-mutated HCT 116 cells, and the mechanism is independent of ERK[2]. In Vivo:Nonactin (intraperitoneal injection; 50-100 mg/kg; 4-5 days) inhibits tumors in the β-catenin mutant HCT 116 mouse xenograft model[2].
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