Ro 07-1902
CAS No. : 68160-71-4
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| Cat. No. : | HY-123371 |
| M.Wt: | 227.22 |
| Formula: | C9H13N3O4 |
| Purity: | >98 % |
| Solubility: |
Ro 07-1902 is a potent antitumor synergist. Ro 07-1902 enhances the antitumor effects of CCNU (HY-13669), Chlorambucil (HY-13593) and Cyclophosphamide (HY-17420). Ro 07-1902 exhibits no single-agent cytotoxicity and does not delay tumor growth. Ro 07-1902 can be used in research related to various cancers[1][2][3].
In Vitro:Ro 07-1902 has an octanol/water partition coefficient of 2.5 at pH 7.4, a value associated with potent enhancement of CCNU's anti-tumour effect in the KHT fibrosarcoma model[1].
In Vivo:Ro 07-1902 (0.1-4.0 mmol/kg; i.p.; single administration) significantly potentiates the antitumor effect of CCNU against KHT fibrosarcoma in C3H/He mice[1].
Ro 07-1902 (1.0-2.0 μmol/g; i.p.; single administration) acts as a potent enhancer of cyclophosphamide cytotoxicity in C57Bl/Cbi mice bearing Lewis lung carcinoma[2].
Ro 07-1902 (1 mmol/kg; i.p.; single administration) enhances the tumor growth delay effect of chlorambucil on RIF-1 mouse sarcoma[3].
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