PIN1 inhibitor API-1
CAS No. : 680622-70-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $820 | In-stock |
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| Cat. No. : | HY-116716 |
| M.Wt: | 366.30 |
| Formula: | C15H13F3N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1]. IC50 & Target: IC50: 72.3 nM (Pin1)[1] In Vitro: PIN1 inhibitor API-1 obviously inhibits SK-Hep-1, SNU-423, and Hep3B cell proliferation with low IC50 values (IC50=0.683-4.16 μM)[1]. In Vivo: PIN1 inhibitor API-1 suppresses tumor growth in mice by up-regulating mature miRNA biogenesis[1].
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