Pulsatilla saponin D


CAS No. : 68027-15-6

(Synonyms: SB365; Hederacolchiside A)

68027-15-6
Price and Availability of CAS No. : 68027-15-6
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Cat. No. : HY-N0834
M.Wt: 913.10
Formula: C47H76O17
Purity: >98 %
Solubility: DMSO : ≥ 39 mg/mL
Introduction of 68027-15-6 :

Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla chinensis, is an anti-tumor agent[1][2][3][4]. In Vitro: Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase[1].
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells[1].
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) [2].
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF[3].
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells[4]. In Vivo: Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4].

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