Hexamethylphosphoramide
CAS No. : 680-31-9
(Synonyms: HMPA)
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|---|---|---|
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| 100g | $15 | In-stock |
| 500g | $30 | In-stock |
| 1000g | $53 | In-stock |
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| Cat. No. : | HY-Y1155 |
| M.Wt: | 179.20 |
| Formula: | C6H18N3OP |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hexamethylphosphoramide is an orally active polar aprotic solvent, flame retardant additive, and carcinogen. Hexamethylphosphoramide undergoes cytochrome P-450-mediated N-demethylation to Formaldehyde. Hexamethylphosphoramide induces DNA-protein crosslinks. Hexamethylphosphoramide has been linked to nasal tumors (squamous cell carcinoma, adenoid squamous cell carcinoma), squamous metaplasia, rhinitis, tracheitis, and reversible and irreversible infertility[1][2][3][4][5][6][7].
In Vitro:Hexamethylphosphoramide (0.2-10 mM; 1 h for DPXLs) undergoes cytochrome P-450-mediated N-demethylation in rat nasal microsomes to produce formaldehyde, induces DNA-protein crosslinks (DPXLs) in plasmid DNA-histone systems[4].
In Vivo:Hexamethylphosphoramide (50-4000 ppb (parts per billion); inhalation; 6-24 months) induces dose-dependent nasal tumors (squamous cell carcinoma, adenoid squamous cell carcinoma), squamous metaplasia, and rhinitis in Charles-CD Sprague-Dawley rats[5].
Hexamethylphosphoramide (10-4000 ppb; inhalation; 6 h/day, 5 days/week; 6-24 months) induces dose-dependent tracheitis, tracheobronchial epithelial degeneration in Charles-CD Sprague-Dawley rats, with keratinized squamous metaplasia in trachea at 4000 ppb[6].
Hexamethylphosphoramide (100-500 mg/kg; p.o.) induces reversible or irreversible sterility (aspermia) in male rats[7].
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