Hydroxyzine
CAS No. : 68-88-2
| Size | Price | Stock |
|---|---|---|
| 25mg | $33 | In-stock |
| 50mg | $47 | In-stock |
| 100mg | $65 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B0548 |
| M.Wt: | 374.90 |
| Formula: | C21H27ClN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C) |
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder[1]. In Vitro: Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min[1]. In Vivo: Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats[3].
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