DL-Cycloserine

DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states^[1]. In Vitro:DL-Cycloserine (0.4-4 mM) significantly inhibits MAO activity in 33% rat liver homogenate and significantly stimulates MAO activity in 50% rat brain homogenate at the same concentrations^[1]. In Vivo:DL-Cycloserine (2000 mg/kg; i.p.; single dose) significantly inhibits liver MAO activity and mildly stimulates brain MAO activity in healthy Wistar rats^[1].
DL-Cycloserine (350-700 mg/kg; p.o.; single dose) significantly suppresses Tryptamine (HY-B2132)-induced convulsions in H Rosice mice^[1].
DL-Cycloserine (350-700 mg/kg; p.o.; single dose) significantly blocks Reserpine (HY-N0480)-induced eyelid ptosis in female H Rosice mice^[1].
DL-Cycloserine (175 mg/kg; p.o.; single dose) induces sedation in female H Rosice mice, following an initial short excitation phase, causing 100% of mice to fail the rotating-rod test by 90 minute^[1].
DL-Cycloserine (87.5-350 mg/kg; p.o.; single dose) significantly potentiates thiopental anaesthesia in female H Rosice mice, and induces hypothermia^[1].