Aurantio-obtusin

Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation^[1][2][3]. In Vitro:Aurantio-obtusin (6.25-100 μM; 24 h) significantly decreases the production of NO and PGE2, and inhibits the expression of IL-6, TNF-α, COX-2 protein in RAW264.7 cells treated with LPS (0.2µg/mL)^[2].
Aurantio-obtusin (6.25-100 μM; 12 h) inhibits the activation of NF-κ B by inhibiting the phosphorylation of i-κB and IKK in RAW264.7 cells treated with LPS (0.2µg/mL)^[1].
Aurantioobtusin (1-10000 nM) induces small resistance vasodilation in rat MA in a concentration-dependent manner^[1].
In Vivo:Aurantio-obtusin (5-15 mg/kg; Oral administration; Single dose) in HFSW-induced mice reduces HFSW-induced lipid droplet accumulation and extensive steatosis in a dose-dependent manner^[3].
Aurantio-obtusin (5-15 mg/kg; Oral administration; A single dose) inhibits fatty acid synthesis, promotes FAO and activates AMPK signaling and autophagy in HFSW-induced mice ^[3].