GPNA (hydrochloride)
CAS No. : 67953-08-6
| Size | Price | Stock |
|---|---|---|
| 10mg | $55 | In-stock |
| 50mg | $165 | In-stock |
| 100mg | $225 | In-stock |
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| Cat. No. : | HY-W011391 |
| M.Wt: | 303.70 |
| Formula: | C11H14ClN3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. IC50 & Target: ASCT2[1] In Vitro: GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1].
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