CLZ-8
CAS No. : 678158-55-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $640 | In-stock |
| 100mg | $1000 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122627 |
| M.Wt: | 393.50 |
| Formula: | C22H23N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
IC50 & Target: Ki: 0.3 μM (Mcl-1)[1].
In Vitro: CLZ-8 (Compound 8) (0-160 μM, 48 h) significantly inhibits PUMA-dependent apoptosis[1].
CLZ-8 (0-1 μM, 2 h) significantly enhance the irradiated cell viability in a dose-dependent manner, provides significant protection for HUVECs, and inhibits overexpressed PUMA[2].
CLZ-8 (0-1 μM, 24 h) attenuates the radiation-induced apoptosis[2].
CLZ-8 (1 μM, 2 h) protects HUVECs from DNA breaks[2].
In Vivo: CLZ-8 (0-400 mg/kg; i.g.; once) shows powerful anti-radiation effects in mice[2].
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