Isepamicin (sulfate)

Isepamicin sulfate (Sch 21420 sulfate) is a broad-spectrum aminoglycoside antibiotic. Isepamicin sulfate has considerable antimicrobial activity against some Gram-negative non-fermenting bacteria that are highly resistant to antibiotics. Isepamicin sulfate inhibits writhing reactions induced by Acetic acid (HY-Y0319), regulates vascular blood flow and blood pressure, and inhibits spontaneous uterine movements. Isepamicin sulfate has antidiuretic and blood sugar-raising effects. Isepamicin sulfate can be used in seizure research^[1][2]. In Vitro:Isepamicin sulfate (0.3-1 mg/mL) inhibits spontaneous beating of isolated atria, spontaneous movement of isolated ileum^[2]. In Vivo:Isepamicin sulfate (12.5-50 mg/kg; i.v.) increases femoral artery blood flow, decreases blood pressure, increases respiratory rate, and increases carotid artery blood flow in anesthetized dogs^[2].
Isepamicin sulfate (100 mg/kg; i.v.) causes an increase in heart rate in conscious rabbits, without significant changes in blood pressure or electrocardiogram^[2].