Etamicastat (hydrochloride)
CAS No. : 677773-32-9
(Synonyms: BIA 5-453 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $390 | In-stock |
| 10mg | $580 | In-stock |
| 50mg | $1300 | In-stock |
| 100mg | $1850 | In-stock |
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| Cat. No. : | HY-14838A |
| M.Wt: | 347.81 |
| Formula: | C14H16ClF2N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 16.67 mg/mL (ultrasonic) |
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].
IC50 & Target: IC50: 107 nM (DBH)[1]
In Vitro: Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL (141 μM)[2].
In Vivo: Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1].
Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats[1].
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