K 01-162
CAS No. : 677746-25-7
(Synonyms: K162)
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $530 | In-stock |
| 100mg | $860 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14533 |
| M.Wt: | 288.18 |
| Formula: | C15H14BrN |
| Purity: | >98 % |
| Solubility: | DMSO : 14.29 mg/mL (ultrasonic) |
K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease[1][2]. In Vitro: K 01-162 (1 μM; 24 h) reduces the level of intracellular AβO[2]. K 01-162 (0.78-50 μM; 5 min) blocks the synaptic binding activity of AβO in mouse hippocampal neurons[2]. In Vivo: K 01-162 (100 μM; intracerebroventricular infusion 0.25 μL/h for 2 weeks) attenuates amyloid load in vivo[2].
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