Facinicline (hydrochloride)
CAS No. : 677305-02-1
(Synonyms: RG3487 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $900 | In-stock |
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| Cat. No. : | HY-108057A |
| M.Wt: | 306.79 |
| Formula: | C15H19ClN4O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].
In Vitro: Facinicline (RG3487) activates human α7 nAChRs with an EC50 of 0.8 μM (oocytes) and 7.7 μM (QM7 cells)[1].
Facinicline (RG3487) exhibits antagonist properties at the serotonin 3 receptor (IC50 2.8 nM (oocytes), 32.7 nM (N1E-115 cells))[1].
In Vivo: Facinicline (RG3487) improves object recognition memory in rats after acute [minimally effective dose (MED) 1.0 mg/kg p.o.] or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range[1].
RG3487 (0.1–10 mg/kg p.o.) selectively enhances object recognition memory[1].
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