1-Azakenpaullone
CAS No. : 676596-65-9
(Synonyms: 1-Akp)
| Size | Price | Stock |
|---|---|---|
| 2mg | $132 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $590 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-59090 |
| M.Wt: | 328.16 |
| Formula: | C15H10BrN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].
IC50 & Target:IC50: 18 nM (GSK-3β), 2 μM (CDK1/cyclin B), 4 μM (CDK5/p25)[1].
In Vitro:1-Azakenpaullone (2.5 μM, 48 h) stimulates proliferation in irradiated zebrafish lateral line neuromasts[2].
1-Azakenpaullone (3 μM, 48 h) induces the osteoblastic differentiation and mineralization of human human mesenchymal stem cells (MSCs), by activating Wnt signaling[3].
1-Azakenpaullone (30 μM, 24 h) reduces S6K1 phosphorylation in HCC1806 cells[5].
In Vivo:1-Azakenpaullone (10 or 100 pmol, i.c.v.) reverses Ketamine (20 mg/kg, i.p.)-induced locomotor hyperactivity and behavioral aberrations in Male NMRI mice[4].
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