RSV604
CAS No. : 676128-63-5
(Synonyms: A-60444)
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $720 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12993 |
| M.Wt: | 388.39 |
| Formula: | C22H17FN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM)[1][2].
IC50 & Target: Kd: 1.6 μM (nucleocapsid protein)[2]
In Vitro: RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC50s ranging from 0.5 to 0.9 μM in plaque reduction assay[1].
RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC50 of 0.86 μM[1].
RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC50 of 1.7 μM[1].
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency[1].
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