Nutlin-3b
CAS No. : 675576-97-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $775 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15335 |
| M.Wt: | 581.49 |
| Formula: | C30H30Cl2N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Nutlin-3b, the inactive form of Nutlin-3 (HY-50696), is a p53/MDM2 inhibitor with an IC50 of 13.6 μM. Nutlin-3b is 150 times less potent in binding to MDM2 than Nutlin-3a (HY-10029). Nutlin-3b is promising for research of cancers[1][2][3][4].
IC50 & Target:IC50: 13.6 μM (MDM2/p53)[1]
In Vitro:Nutlin-3b (0-8 μM, 8 h) shows a potent antiproliferative activity in MDA-MB-435 and SW480 cells harboring mutant p53[1].
Nutlin-3b (10 μM, 24 h and 48 h) has no influence on cell proliferation and apoptosis in wild-type p53 (HCT116)[1].
Nutlin-3b (10 μM, 4, 24 and 48 h) slightly decreases p53 mRNA levels in sensitive liposarcoma cells[2].
Nutlin-3b (20 μM, 60 min) interfere with P-gp-mediated drug efflux in UKF-NB-3rVCR10 neuroblastoma cells[3].
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