DIDS (sodium salt)
CAS No. : 67483-13-0
(Synonyms: MDL101114ZA)
| Size | Price | Stock |
|---|---|---|
| 5mg | $29 | In-stock |
| 10mg | $40 | In-stock |
| 50mg | $80 | In-stock |
| 100mg | $138 | In-stock |
| 250mg | $240 | In-stock |
| 500mg | $360 | In-stock |
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| Cat. No. : | HY-D0086 |
| M.Wt: | 498.48 |
| Formula: | C16H8N2Na2O6S4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 33.33 mg/mL (ultrasonic) |
DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. IC50 & Target: ABCA1[1], VDAC1[2]. In Vitro: Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation[2].
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