Vanoxerine (dihydrochloride)
CAS No. : 67469-78-7
(Synonyms: GBR-12909 dihydrochloride; I893 dihydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $95 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $215 | In-stock |
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| Cat. No. : | HY-13217 |
| M.Wt: | 523.49 |
| Formula: | C28H34Cl2F2N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 9.4 mg/mL (ultrasonic;warming);H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT)[1].
IC50 & Target: Ki: 1 nM (dopamine reuptake)[1]
In Vitro: Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2].
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3].
In Vivo: Vanoxerine dihydrochloride (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity[3].
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