GBR 12783 (dihydrochloride)
CAS No. : 67469-75-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $94 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $350 | In-stock |
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| Cat. No. : | HY-100968 |
| M.Wt: | 485.49 |
| Formula: | C28H34Cl2N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C) |
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. In Vivo: GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].
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