Vanoxerine
CAS No. : 67469-69-6
(Synonyms: GBR 12909; I893)
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| Cat. No. : | HY-13217A |
| M.Wt: | 450.56 |
| Formula: | C28H32F2N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT)[1].
IC50 & Target: Ki: 1 nM (dopamine reuptake)[1]
In Vitro: Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2].
Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3].
In Vivo: Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity[3].
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