GBR 12783
CAS No. : 67469-57-2
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| Cat. No. : | HY-W008610 |
| M.Wt: | 412.57 |
| Formula: | C28H32N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. In Vivo: GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].
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